Pharmacogenomics

424 pages, Illustrated  ISBN 0824705440      £109.00

This book, volume 113 in the series Drugs and the Pharmaceutical Science, summarises the history of and available applications, techniques and approaches to pharmacogenomics aimed at improving efficacy and tolerance to pharmaceutical compounds, evaluating pharmacogenomics on clinical trial design and increasing the chances of successful clinical trials and patient outcomes. It compares pharmacogenomics to pharmacogenetics, focusing on the components in which individual genetic variations to drug regimens result in different responses to therapeutics. It will be of interest to pharmaceutical scientists and biotechnologists; neurobiologists, neuroscientists, and neurochemists; medical and human geneticists and pharmacogencticists; molecular and cell biologists and biochemists; microbiologists and toxicologists as well as medical students.

Contents

• Historical aspects of pharmacogenomics;
• pharmacogenomics, biomarkers and the promise of personalized medicine;
• current status - pharmacogenetics/drug metabolism;
• pharmacogenetics -receptors;
• pharmacogenetics of drug transporters;
• interethnic differences in drug response;
• pharmacogenetics - clinical viewpoints;
• tools of the trade - the technologies and challenges of pharmacogenetics;
• molecular diagnostics and development of biotechnology-based diagnostics;
• technologies for the analysis of single-nucleotide polymorphisms - an overview;
• multiplex fluorescent minisequencing applied to the typing of genes encoding drug-metabolizing enzymes;
• multiplex genotyping by specialized mass spectrometry;
• serial analysis of gene expression -transcriptional insights into functional biology;
• proteomics;
• bioinformatics - WWW resources;
• applied bioinformatics;
• mapping of disease loci; positional cloning and disease gene identification;
• general conclusions and future directions.