Mass Spectrometry in Drug Discovery

432 pages, Illustrated  ISBN 0824706072      £99.00

This book covers the theory, instrumentation, and principles of mass spectrometry and atmospheric pressure ionisation. It also discusses new strategies for novel drug detection and development and identifies recent applications of mass spectrometry in chemical libraries, combinatorial chemistry, and pharmacology. It will be of interest to spectrometrists; pharmacologists; analytical; medicinal, and organic chemists and biochemists; biotechnologists; pharmaceutical scientists and toxicologists as well as advanced undergraduate and graduate students.

Contents

Introduction: the demand for drug discovery today; the impact of atmospheric pressure ionisation.

Part 1 Instrumentation: a mass spectrometry primer.

Part 2 Experimental strategies: ion chemistry and fragmentation;
the LC/MS experiment;
sample preparation and handling for LC/MS in drug discovery.

Part 3 Applications: mass spectrometry in combinatorial chemistry;
drug hydrophobicity and transport;
the mass spectrometer in drug metabolism;
mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies;
cassette dosing in drug discovery;
applications of microdialysis/mass spectrometry to drug discovery;
future directions for mass spectrometry in drug discovery.