Optimization of Solid-Phase Combinatorial Synthesis

408 pages, Illustrated  ISBN 0824706544      £100.00

This book addresses the key topics in combinatorial synthesis, how to optimise the quality of a combinatorial library by determining the usefulness of synthesised compounds and the reliability of biological assay results. It also analyses academic and industrial applications of this technology providing real-world examples and case studies of successful and unsuccessful technologies. It will be of interest to organic, analytical, medicinal, pharmaceutical, computational, protein, and peptide chemists and biochemists; pharmacists; pharmacologists; molecular biologists; molecular and vibrational spectroscopists as well as advanced students in these disciplines.

Contents

• Basic principles and theory;
• NIR instrumentation;
• blending;
• coating and drying;
• pharmaceutical applications;
• validation;
• medical applications.