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Carbohydrate Chemistry, Biology and Medical Applications
Edited by Hari G. Garg, Mary K. Cowman and Charles A. Hales
Elsevier
2008
Hardcover 432 pp ISBN 9780080548166
£72.00
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The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave
the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then,
progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis,
immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins
and proteoglycans). The chapters in this book present a logical sequence leading from the chemistry and biochemistry
of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic
and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates
for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular
area of research.
Of interest to physicians, glycobiologists, pharmaceutical scientists, and graduate students, medical
libraries and institutes/corporates researching the medical aspects of carbohydrates
Contents
Preface
Contributors list
- The Development of Carbohydrate Chemistry and Biology (D. Horton)
- Carbohydrate Structure Determination by Mass Spectrometry (B. Xie and C.E. Costello)
- Chemical Synthesis of Complex Carbohydrates (Z. Guo)
- Enzymatic Synthesis of Oligosaccharides and Conversion to Glycolipids (D.M. Su, H. Eguchi, C. Xia, J. Song,
W. Yi, R.L. Woodward and P.G. Wang)
- Proteoglycans in the Lung (M.S. Ludwig)
- Proteoglycans of the Intervertebral Disc (P.J. Roughley)
- Small Leucine Rich-Repeat Proteoglycans of Skin (P.G. Scott)
- Functional Glycosaminoglycans in the Eye (M. Zako and M. Yoneda)
- Biological Function of Glycosaminoglycan (M. Roth, E. Papakonstantinou and G. Karakiulakis)
- Physiological, Pathophysical and Therapeutic Roles of Heparin/Heparan Sulfate (J. Xie, S. Murugesan and R.J. Linhardt)
- Carbohydrates and Cutaneous Wound Healing (A. Burd and L. Huang)
- Carbohydrates in Human Milk and Infant Formulas (G. Boehm, B. Stahl, J. Knol and J. Garssen)
- Role of Cell Surface Carbohydrates in Development and Disease (M.N. Fukuda, T.O. Akama and K. Sugihara)
- Therapeutic Use of Hyaluronan-Based Derived Products (E.A. Balazs and P.A. Band)
- Drug Delivery and Medical Applications of Chemically Modified Hyaluronan (L.Z. Avila, D.A. Gianolio, P.A. Konowicz, M. Philbrook, M.R. Santos and R.J. Miller)
- Carbohydrate Microarrays as Essential Tools of Postgenomic Medicine (X. Zhou, G.T. Carroll, C. Turchi and D. Wang)
- Carbohydrate Arrays for Basic Science and as Diagnostic Tools (T. Horlacher, J.L. de Paz and P.H. Seeberger)
Subject Index
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