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Analytical Techniques for Biopharmaceutical Development
Roberto Rodriguez-Diaz; Tim Wehr; Stephen Tuck
Marcell Dekker
2005
Hardback 424 pp ISBN 0824726677
£115.00
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Examining methods to ensure the purity, potency, quality, and performance of drug compounds, this handbook
provides
- clear and concise descriptions of various techniques for protein analysis
- organizes chapters according to the order in which one might encounter the methods in the biopharmaceutical cycle
- describes the advantages and limitations of each analytical technique and identifies the most appropriate stage
of application during the drug development process
- assesses each method discussed for its efficacy in characterizing the performance, primary sequence,
conformation, post-translational modification, stability, degradation, and metabolism of various protein-based
pharmaceuticals
This reference assists scientists in the selection and application of analytical techniques for biopharmaceutical
identification, formulation, and assessment-providing a valuable survey of exploratory methods commonly
utilized during the preclinical, clinical, and commercial phases of development.
Contents
- Overview.
- Protein Assay.
- Reversed-Phase Chromatography.
- Ion Exchange Chromatography.
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Hydrophobic Interaction Chromatography.
- Size Exclusion Chromatography.
- Gel Electrophoresis.
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Capillary Electrophoresis.
- Mass Spectrometry.
- ELISA.
- NMR Spectroscopy.
- Microcalorimetry.
- Vibrational Spectroscopy.
To find similar publications, click on a keyword below:
Marcel Dekker
: NMR
: analytical methods
: chromatography
: electrochemical methods
: pharmaceuticals
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